| Entry | Kininogen-1 |
| Uniprot code | A5PG36 |
| Fasta | A5PG36 |
| Peptide names | RR-13 Kininogen-1 bradykinin RR-13-(Phe12) RR-13 RR-13-(Glu2,Asn3) AA-15 |
| Suborder | Neobatrachia |
| Family | Ranidae |
| Genus | Lithobates |
| Species | Lithobates palustris |
| Ecozone | Palearctic |
| Distribution | Eastern North America, from southern Quebec through southern Ontario (Canada) south through extreme eastern Minnesota and on to East Texas then east to South Carolina (USA), extreme western Florida, and north to Nova Scotia (Canada) |
| Antimicrobial & other activities | contraction of small intestine smooth muscle cells, relaxation of arterial smooth muscle cells |
| Tissue | Skin |
| Sequence | MFTLKKSLLLLFFLGTISLSLCEQERDADEDEYAGDAKAEDVKRAGYSRVISLPAGLSPL RIAPASSRMIRRPPGFSPFRIAPASTLKRDADEDEYAGEAKAEDVKRAGYSRVISLPAGL SPFRIAPASTLKRDADEDEYAGEAKAEDVKRAGYARVISLPAGLSPLRIAPASTLKRDAD EDEYAGEAKAEDVKRAGYARVISLPAGLSPLRIAPASTLKRDADEDEYAGEAKAEDVKRA RYSRENSLPAGLSPLRIAPASTLKRDADEDEYAGEAKAEDVKRAGIRRPPGFSPLRIAPA SSRMIRRPPGFSPFRIAPAIV |
| Length | 321 |
| Signal peptide class | Class-1 |
| References: | |
| 2. for other activities | T. Chen et al. / Peptides 23 (2002) 1547-1555. Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis) |
| Segment type | Name | Length | Amidated | Sequence | HC50 (μM) | MIC E. coli (μM) | MIC S. aureus (μM) |
| Signal | 22 | MFTLKKSLLLLFFLGTISLSLC | |||||
| Prepro | 26 | EQERDADEDEYAGDAKAEDVKRAGYS | |||||
| Bioactive | RR-13 | 13 | No | RVISLPAGLSPLR | |||
| Prepro | 10 | IAPASSRMIR | |||||
| Bioactive | bradykinin | 9 | No | RPPGFSPFR | |||
| Prepro | 31 | IAPASTLKRDADEDEYAGEAKAEDVKRAGYS | |||||
| Bioactive | RR-13-(Phe12) | 13 | No | RVISLPAGLSPFR | |||
| Prepro | 31 | IAPASTLKRDADEDEYAGEAKAEDVKRAGYA | |||||
| Bioactive | RR-13 | 13 | No | RVISLPAGLSPLR | |||
| Prepro | 31 | IAPASTLKRDADEDEYAGEAKAEDVKRAGYA | |||||
| Bioactive | RR-13 | 13 | No | RVISLPAGLSPLR | |||
| Prepro | 31 | IAPASTLKRDADEDEYAGEAKAEDVKRARYS | |||||
| Bioactive | RR-13-(Glu2,Asn3) | 13 | No | RENSLPAGLSPLR | |||
| Prepro | 27 | IAPASTLKRDADEDEYAGEAKAEDVKR | |||||
| Bioactive | AA-15 | 15 | No | AGIRRPPGFSPLRIA | |||
| Prepro | 8 | PASSRMIR | |||||
| Bioactive | bradykinin | 9 | No | RPPGFSPFR |