Esculentin-2PLa

Entry Esculentin-2PLa
Uniprot code A7WNV5
Fasta A7WNV5
Peptide names Esculentin-2PLa
Suborder Neobatrachia
Family Ranidae
Genus Lithobates
Species Lithobates palustris
Ecozone Palearctic
Distribution Eastern North America, from southern Quebec through southern Ontario (Canada) south through extreme eastern Minnesota and on to East Texas then east to South Carolina (USA), extreme western Florida, and north to Nova Scotia (Canada)
Antimicrobial & other activities antibacterial, antifungal
Tissue Skin
Sequence MFTTKKSMLLLFFLGTISLSLCEEERGADEEEGDGEKLMKRGLFSILKGVGKIALKGLAK
NMGKMGLDLVSCKISKEC
Length 78
Signal peptide class Class-1
References:
1. for MIC/HC50 Y.J. Basir et al. / Biochimica et Biophysica Acta 1543 (2000) 95-105. Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MFTTKKSMLLLFFLGTISLSLC    
Prepro19 EEERGADEEEGDGEKLMKR   
BioactiveEsculentin-2PLa37NoGLFSILKGVGKIALKGLAKNMGKMGLDLVSCKISKEC 110