Nigrocin-2

Entry Nigrocin-2
Uniprot code B0B2H6
Fasta B0B2H6
Peptide names Nigrocin-2 Nigrocin-2H Nigrocin-2P
Suborder Neobatrachia
Family Ranidae
Genus Rana
Species Pelophylax nigromaculatus
Ecozone Palearctic
Distribution Lower Amur and Ussuri River valleys (Far East Russia) through northeastern to west-central China, and the Korean Peninsula; Japan (Honshu, Shikoku, and Kyushu), below 2200 m elevation. Isolated populations in eastern Turkmenistan and Yunnan (likely introduced)
Antimicrobial & other activities antibacterial
Tissue Skin
Sequence MFTTKKSILLLFFLGMVSLALCEQERDANEEERRDELDERDVEAIKRGLLSKVLGVGKKV
LCGVSGLC
Length 68
Signal peptide class Class-1
References:
1. for MIC/HC50 L. Wang et al. / FEBS Journal 277 (2010) 1519-1531. Nigrocin-2 peptides from Chinese Odorrana frogs - integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MFTTKKSILLLFFLGMVSLALC    
Prepro25 EQERDANEEERRDELDERDVEAIKR   
BioactiveNigrocin-221NoGLLSKVLGVGKKVLCGVSGLC 515