Maximin 25/H17

Entry Maximin 25/H17
Uniprot code B5L133
Fasta B5L133
Peptide names Maximin 25 Maximin 25/H17 Maximin 3 Maximin H17
Suborder Archeobatrachia
Family Bombinatoridae
Genus Bombina
Species Bombina maxima
Ecozone Palearctic, Indomalaya
Distribution Yunnan, southwestern Sichuan, Hubei, Guizhou, and northern Guangxi, China; adjacent northern Vietnam
Antimicrobial & other activities antibacterial, antifungal, anticancer, anti-HIV-1, spermicidal
Tissue Skin, Brain
Sequence MNFKYIVAVSFLIASAYARSEENDEQSLSQRDVLEEESLREIRGIGGKILSGLKTALKGA
AKELASTYLHRRRTAEEHEVMKRLEAVMRDLDSLDYPEEASERETRGFNQDEIANLFTKK
EKRILGPVLSLVGNALGGLIKKIG
Length 144
Signal peptide class Class-3
References:
1. for MIC/HC50 R. Liu et al. / Journal of Proteome Research 10 (2011) 1806-1815. There are abundant antimicrobial peptides in brains of two kinds of Bombina toads
2. for other activities R. Lai et al. / Peptides 23 (2002) 427-435. Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   18   MNFKYIVAVSFLIASAYA    
Prepro25 RSEENDEQSLSQRDVLEEESLREIR   
BioactiveMaximin 2527YesGIGGKILSGLKTALKGAAKELASTYLH1003.51.74
Prepro53 RRRTAEEHEVMKRLEAVMRDLDSLDYPEEASERETRGFNQDEIANLFTKKEKR   
BioactiveMaximin H1720NoILGPVLSLVGNALGGLIKKI