Antimicrobial peptide

Entry Antimicrobial peptide
Uniprot code C3RST9
Fasta C3RST9
Peptide names Antimicrobial peptide Maximin H7
Suborder Archeobatrachia
Family Bombinatoridae
Genus Bombina
Species Bombina maxima
Ecozone Palearctic, Indomalaya
Distribution Yunnan, southwestern Sichuan, Hubei, Guizhou, and northern Guangxi, China; adjacent northern Vietnam
Antimicrobial & other activities antibacterial; Maximin H7: antibacterial, antifungal
Tissue Skin
Sequence MKFKYIVAVSFLIASAYARSEENDEQSLSQRDVLEEESLREIRGIGTKFLGGLKTAVKGA
LKELAFTYVNGKRTAEDHEVMKRLEAVMRDLDSLDYPEEAFERETRGFNQEEITNLFTKK
EKRILGPVIKTIGGVIGGLLKNLG
Length 144
Signal peptide class Class-3
References:
1. for MIC/HC50 R. Liu et al. / Journal of Proteome Research 10 (2011) 1806-1815. There are abundant antimicrobial peptides in brains of two kinds of Bombina toads


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   18   MKFKYIVAVSFLIASAYA    
Prepro25 RSEENDEQSLSQRDVLEEESLREIR   
BioactiveAntimicrobial peptide27NoGIGTKFLGGLKTAVKGALKELAFTYVN   
Prepro53 GKRTAEDHEVMKRLEAVMRDLDSLDYPEEAFERETRGFNQEEITNLFTKKEKR   
BioactiveMaximin H720YesILGPVIKTIGGVIGGLLKNL90 4.76