Antimicrobial peptide

Entry Antimicrobial peptide
Uniprot code C3RT13
Fasta C3RT13
Peptide names Antimicrobial peptide Ranacyclin-B-LK2
Suborder Neobatrachia
Family Ranidae
Genus Limnonectes
Species Limnonectes kuhlii
Ecozone Indomalaya
Distribution Mountains of Java; populations of closely related, but apparently unnamed species, from Assam (India) to Indochina to the Greater Sundas as far as Sulawesi, Indonesia
Antimicrobial & other activities antibacterial, trypsin inhibitor
Tissue Skin
Sequence MFTMKKSLLLLFFLGIVSLSLCGQERDADEEDGGEVTEEDVKRSALVGCWTKSWPPKPCF
GR
Length 62
Signal peptide class Class-1
References:
1. for MIC/HC50 X. Yan et al. / Amino Acids (2011) DOI 10.1007/s00726-011-1079-8. Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensivemolecules in Ranidae amphibian skins


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MFTMKKSLLLLFFLGIVSLSLC    
Prepro21 GQERDADEEDGGEVTEEDVKR   
BioactiveAntimicrobial peptide19NoSALVGCWTKSWPPKPCFGR 23.611.8