Odorranain-B4

Entry Odorranain-B4
Uniprot code D0PRC0
Fasta D0PRC0
Peptide names Odorranain-B4 Ranacyclin B3
Suborder Neobatrachia
Family Ranidae
Genus Odorrana
Species Odorrana grahami
Ecozone Palearctic, Indomalaya
Distribution Sichuan, Guizhou, and central and western Yunnan, China; a distantly alloparic population present in southern Shanxi, China: presumably to be found in eastern Myanmar along the Yunna, China, border; reported in Lao Cai and Lai Chau provinces, Vietnam, 1150-3200 m elevation
Antimicrobial & other activities antibacterial, antifungal, trypsin inhibitor
Tissue Skin
Sequence MFTLKKSLFVLFFLGIVSLSVCEHNRDADEEDGGEAIGGEVRRAALKGCWTKSIPPKPCS
GKR
Length 63
Signal peptide class Class-1
References:
1. for MIC/HC50 X. Yan et al. / Amino Acids (2011) DOI 10.1007/s00726-011-1079-8. Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensivemolecules in Ranidae amphibian skins


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MFTLKKSLFVLFFLGIVSLSVC    
Prepro21 EHNRDADEEDGGEAIGGEVRR   
BioactiveOdorranain-B420NoAALKGCWTKSIPPKPCSGKR  11.7