Preprocaerulein type-3

Entry Preprocaerulein type-3
Uniprot code P05224
Fasta P05224
Peptide names Caerulein Preprocaerulein type-3
Suborder Mesobatrachia
Family Pipidae
Genus Xenopus
Species Xenopus laevis
Ecozone Afrotropic
Distribution Extreme southern Angola south to Cape Region of Rep. South Africa thence east and north in savanna habitats to north-east-central Central African Republic and southern Sudan and then west to Nigeria; introduced in southern California, Arizona, USA, Mexico, Chile, France, Mexico, Italy, and Java, Indonesia, as well as Ascension Island
Antimicrobial & other activities fall of the blood pressure, contraction of the gall bladder, stimulating acid secretion of the stomach, increasing the pancreatic juice secretion
Tissue Skin
Sequence MFKGILLCVLFAVLSANPLSQPEGFADEERDVRGLASLLGKALKAGLKIGTHFLGGAPQQ
REANDERRFADGQQDYTGWMDFGRRDGQQDYTGWMDFGRRDDEDDVNERDVRGFGSFLGK
ALKAALKIGANALGGAPQQREANDERRFADGQQDYTGWMDFGRRNGEDD
Length 169
Signal peptide class Class-4
References:
2. for other activities A. Anastasi et al. / British Journal of Pharmacology 38 (1970) 221-228. Presence of caerulein in extracts of the skin of Leptodactylus pentadactylus labyrinthicus and of Xenopus laevis


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   26   MFKGILLCVLFAVLSANPLSQPEGFA    
Prepro46 DEERDVRGLASLLGKALKAGLKIGTHFLGGAPQQREANDERRFADG   
BioactiveCaerulein10NoQQDYTGWMDF   
Prepro5 GRRDG   
BioactiveCaerulein10NoQQDYTGWMDF   
Prepro54 GRRDDEDDVNERDVRGFGSFLGKALKAALKIGANALGGAPQQREANDERRFADG   
BioactiveCaerulein10NoQQDYTGWMDF