Grahamin-2

Entry Grahamin-2
Uniprot code P0C2A5
Fasta P0C2A5
Peptide names Grahamin-1 Grahamin-2 Nigrocin-2GRa Nigrosin-OG20 Nigrosin-RA2
Suborder Neobatrachia
Family Ranidae
Genus Odorrana
Species Odorrana grahami
Ecozone Palearctic, Indomalaya
Distribution Sichuan, Guizhou, and central and western Yunnan, China; a distantly alloparic population present in southern Shanxi, China: presumably to be found in eastern Myanmar along the Yunna, China, border; reported in Lao Cai and Lai Chau provinces, Vietnam, 1150-3200 m elevation
Antimicrobial & other activities antibacterial, antifungal
Tissue Skin
Sequence MFTLKKSQLLLFFPGTINLSLCQDETNAEEERRDEEVAKMEEIKRGLLSGILGAGKHIVC
GLSGLC
Length 66
Signal peptide class Class-1
References:
1. for MIC/HC50 J.M. Conlon et al. / Peptides 27 (2006) 2111-2117. Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami
2. for other activities X. Xu et al. / Toxicon 47 (2006) 459-464. Two antimicrobial peptides from skin secretions of Rana grahami


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MFTLKKSQLLLFFPGTINLSLC    
Prepro23 QDETNAEEERRDEEVAKMEEIKR   
BioactiveGrahamin-221NoGLLSGILGAGKHIVCGLSGLC29525