Entry | Magainins |
Uniprot code | P11006 |
Fasta | P11006 |
Peptide names | Magainin-1 Magainins Magainin-2 Magainin 2 |
Suborder | Mesobatrachia |
Family | Pipidae |
Genus | Xenopus |
Species | Xenopus laevis |
Ecozone | Afrotropic |
Distribution | Extreme southern Angola south to Cape Region of Rep. South Africa thence east and north in savanna habitats to north-east-central Central African Republic and southern Sudan and then west to Nigeria; introduced in southern California, Arizona, USA, Mexico, Chile, France, Mexico, Italy, and Java, Indonesia, as well as Ascension Island |
Antimicrobial & other activities | antibacterial; Magainin-2: antibacterial, antifungal |
Tissue | Skin, Stomach |
Sequence | MFKGLFICSLIAVICANALPQPEASADEDMDEREVRGIGKFLHSAGKFGKAFVGEIMKSK RDAEAVGPEAFADEDLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAFADE DLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAFADEDLDEREVRGIGKFL HSAKKFGKAFVGEIMNSKRDAEAVGPEAFADEDFDEREVRGIGKFLHSAKKFGKAFVGEI MNSKRDAEAVGPEAFADEDLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVDDRR WVE |
Length | 303 |
Signal peptide class | Class-4 |
References: | |
1. for MIC/HC50 | K. Matsuzaki et al. / Biochimica et Biophysica Acta 1327 (1997) 119-130. Interactions of an antimicrobial peptide, magainin 2, with outer and inner membranes of Gram-negative bacteria |
Segment type | Name | Length | Amidated | Sequence | HC50 (μM) | MIC E. coli (μM) | MIC S. aureus (μM) |
Signal | 18 | MFKGLFICSLIAVICANA | |||||
Prepro | 18 | LPQPEASADEDMDEREVR | |||||
Bioactive | Magainin-1 | 23 | No | GIGKFLHSAGKFGKAFVGEIMKS | |||
Prepro | 23 | KRDAEAVGPEAFADEDLDEREVR | |||||
Bioactive | Magainin-2 | 23 | No | GIGKFLHSAKKFGKAFVGEIMNS | 1000 | 50 | |
Prepro | 23 | KRDAEAVGPEAFADEDLDEREVR | |||||
Bioactive | Magainin-2 | 23 | No | GIGKFLHSAKKFGKAFVGEIMNS | 1000 | 50 | |
Prepro | 23 | KRDAEAVGPEAFADEDLDEREVR | |||||
Bioactive | Magainin-2 | 23 | No | GIGKFLHSAKKFGKAFVGEIMNS | 1000 | 50 | |
Prepro | 23 | KRDAEAVGPEAFADEDFDEREVR | |||||
Bioactive | Magainin-2 | 23 | No | GIGKFLHSAKKFGKAFVGEIMNS | 1000 | 50 | |
Prepro | 23 | KRDAEAVGPEAFADEDLDEREVR | |||||
Bioactive | Magainin-2 | 23 | No | GIGKFLHSAKKFGKAFVGEIMNS | 1000 | 50 |