Magainins

Entry Magainins
Uniprot code P11006
Fasta P11006
Peptide names Magainin-1 Magainins Magainin-2 Magainin 2
Suborder Mesobatrachia
Family Pipidae
Genus Xenopus
Species Xenopus laevis
Ecozone Afrotropic
Distribution Extreme southern Angola south to Cape Region of Rep. South Africa thence east and north in savanna habitats to north-east-central Central African Republic and southern Sudan and then west to Nigeria; introduced in southern California, Arizona, USA, Mexico, Chile, France, Mexico, Italy, and Java, Indonesia, as well as Ascension Island
Antimicrobial & other activities antibacterial; Magainin-2: antibacterial, antifungal
Tissue Skin, Stomach
Sequence MFKGLFICSLIAVICANALPQPEASADEDMDEREVRGIGKFLHSAGKFGKAFVGEIMKSK
RDAEAVGPEAFADEDLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAFADE
DLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAFADEDLDEREVRGIGKFL
HSAKKFGKAFVGEIMNSKRDAEAVGPEAFADEDFDEREVRGIGKFLHSAKKFGKAFVGEI
MNSKRDAEAVGPEAFADEDLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVDDRR
WVE
Length 303
Signal peptide class Class-4
References:
1. for MIC/HC50 K. Matsuzaki et al. / Biochimica et Biophysica Acta 1327 (1997) 119-130. Interactions of an antimicrobial peptide, magainin 2, with outer and inner membranes of Gram-negative bacteria


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   18   MFKGLFICSLIAVICANA    
Prepro18 LPQPEASADEDMDEREVR   
BioactiveMagainin-123NoGIGKFLHSAGKFGKAFVGEIMKS   
Prepro23 KRDAEAVGPEAFADEDLDEREVR   
BioactiveMagainin-223NoGIGKFLHSAKKFGKAFVGEIMNS100050 
Prepro23 KRDAEAVGPEAFADEDLDEREVR   
BioactiveMagainin-223NoGIGKFLHSAKKFGKAFVGEIMNS100050 
Prepro23 KRDAEAVGPEAFADEDLDEREVR   
BioactiveMagainin-223NoGIGKFLHSAKKFGKAFVGEIMNS100050 
Prepro23 KRDAEAVGPEAFADEDFDEREVR   
BioactiveMagainin-223NoGIGKFLHSAKKFGKAFVGEIMNS100050 
Prepro23 KRDAEAVGPEAFADEDLDEREVR   
BioactiveMagainin-223NoGIGKFLHSAKKFGKAFVGEIMNS100050