| Entry | Magainins |
| Uniprot code | P11006 |
| Fasta | P11006 |
| Peptide names | Magainin-1 Magainins Magainin-2 Magainin 2 |
| Suborder | Mesobatrachia |
| Family | Pipidae |
| Genus | Xenopus |
| Species | Xenopus laevis |
| Ecozone | Afrotropic |
| Distribution | Extreme southern Angola south to Cape Region of Rep. South Africa thence east and north in savanna habitats to north-east-central Central African Republic and southern Sudan and then west to Nigeria; introduced in southern California, Arizona, USA, Mexico, Chile, France, Mexico, Italy, and Java, Indonesia, as well as Ascension Island |
| Antimicrobial & other activities | antibacterial; Magainin-2: antibacterial, antifungal |
| Tissue | Skin, Stomach |
| Sequence | MFKGLFICSLIAVICANALPQPEASADEDMDEREVRGIGKFLHSAGKFGKAFVGEIMKSK RDAEAVGPEAFADEDLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAFADE DLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAFADEDLDEREVRGIGKFL HSAKKFGKAFVGEIMNSKRDAEAVGPEAFADEDFDEREVRGIGKFLHSAKKFGKAFVGEI MNSKRDAEAVGPEAFADEDLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVDDRR WVE |
| Length | 303 |
| Signal peptide class | Class-4 |
| References: | |
| 1. for MIC/HC50 | K. Matsuzaki et al. / Biochimica et Biophysica Acta 1327 (1997) 119-130. Interactions of an antimicrobial peptide, magainin 2, with outer and inner membranes of Gram-negative bacteria |
| Segment type | Name | Length | Amidated | Sequence | HC50 (μM) | MIC E. coli (μM) | MIC S. aureus (μM) |
| Signal | 18 | MFKGLFICSLIAVICANA | |||||
| Prepro | 18 | LPQPEASADEDMDEREVR | |||||
| Bioactive | Magainin-1 | 23 | No | GIGKFLHSAGKFGKAFVGEIMKS | |||
| Prepro | 23 | KRDAEAVGPEAFADEDLDEREVR | |||||
| Bioactive | Magainin-2 | 23 | No | GIGKFLHSAKKFGKAFVGEIMNS | 1000 | 50 | |
| Prepro | 23 | KRDAEAVGPEAFADEDLDEREVR | |||||
| Bioactive | Magainin-2 | 23 | No | GIGKFLHSAKKFGKAFVGEIMNS | 1000 | 50 | |
| Prepro | 23 | KRDAEAVGPEAFADEDLDEREVR | |||||
| Bioactive | Magainin-2 | 23 | No | GIGKFLHSAKKFGKAFVGEIMNS | 1000 | 50 | |
| Prepro | 23 | KRDAEAVGPEAFADEDFDEREVR | |||||
| Bioactive | Magainin-2 | 23 | No | GIGKFLHSAKKFGKAFVGEIMNS | 1000 | 50 | |
| Prepro | 23 | KRDAEAVGPEAFADEDLDEREVR | |||||
| Bioactive | Magainin-2 | 23 | No | GIGKFLHSAKKFGKAFVGEIMNS | 1000 | 50 |