[D-Ala2]-deltorphins

Entry [D-Ala2]-deltorphins
Uniprot code P21850
Fasta P21850
Peptide names [D-Ala2]-dermorphin-like [D-Ala2]-deltorphins [D-Ala2]-deltorphin-2 [D-Ala2]-deltorphin-1
Suborder Neobatrachia
Family Hylidae
Genus Phyllomedusa
Species Phyllomedusa bicolor
Ecozone Neotropic
Distribution Amazon Basin in Brazil, Colombia, Bolivia, and Peru; the Guianan region of Venezuela and the Guianas. Possibly to be found in eastern Ecuador
Antimicrobial & other activities inhibition of ileum cells contraction, inhibition of vas deferens cells contraction, mu-receptor affinity, delta-receptor affinity, antinociceptive
Tissue Skin
Sequence MSFLKKSLLLVLFLGLVSHSVCKEEKRETEEENENEEENHEVGSEMKRYAFWYPNRDTEE
KNENEEENQEEGSEMKRYAFGYPKREPEEENENEEENHEEGSEMKRYAFEVVGGEAKKMK
REPEEENENEEENHEEGSEMKRYAFDVVGGEAKKMKREPEEENENEEENHEEGSEMKRYA
FDVVGGEAKKMKREPEEENENEEENHEEGSEMKRYAFDVVGGEAKKM
Length 227
Signal peptide class Class-1
References:
2. for other activities K. Richter et al. / PNAS 87 (1990) 4836-4839. cDNAs encoding [D-Ala2]deltorphin precursors from skin of Phyllomedusa bicolor also contain genetic information for three dermorphin-related opioid peptides


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MSFLKKSLLLVLFLGLVSHSVC    
Prepro26 KEEKRETEEENENEEENHEVGSEMKR   
Bioactive[D-Ala2]-dermorphin-like7NoYAFWYPN   
Prepro22 RDTEEKNENEEENQEEGSEMKR   
Bioactive[D-Ala2]-dermorphin-like6NoYAFGYP   
Prepro23 KREPEEENENEEENHEEGSEMKR   
Bioactive[D-Ala2]-deltorphin-27NoYAFEVVG   
Prepro29 GEAKKMKREPEEENENEEENHEEGSEMKR   
Bioactive[D-Ala2]-deltorphin-17NoYAFDVVG   
Prepro29 GEAKKMKREPEEENENEEENHEEGSEMKR   
Bioactive[D-Ala2]-deltorphin-17NoYAFDVVG   
Prepro29 GEAKKMKREPEEENENEEENHEEGSEMKR   
Bioactive[D-Ala2]-deltorphin-17NoYAFDVVG