Bombinin-like peptides 1

Entry Bombinin-like peptides 1
Uniprot code P29006
Fasta P29006
Peptide names Bombinin-like peptide 1 Bombinin-like peptides 1 Bombinin-H Bombinin H2 Bombinin H5
Suborder Archeobatrachia
Family Bombinatoridae
Genus Bombina
Species Bombina variegata
Ecozone Palearctic
Distribution Europe excluding the Iberian Peninsula and Italy south of the Po River in Italy, east to western Ukraine and Moldova; introduced into England
Antimicrobial & other activities antibacterial; Bombinin-H: antibacterial, antifungal, antiprotozoa
Tissue Skin, Brain, Stomach
Sequence MNFKYIVAVSILIASAYARSEENDIQSLSQRDVLEEESLREIRGIGGALLSAAKVGLKGL
AKGLAEHFANGKRTAEEREVMKRLEAAMRDLDSFEHPEEASEKETRGFNQEEKEKRIIGP
VLGLVGSALGGLLKKIG
Length 137
Signal peptide class Class-3
References:
1. for MIC/HC50 M. Simmaco et al. / Biochimica et Biophysica Acta 1788 (2009) 1551-1555. Bombinins, antimicrobial peptides from Bombina species
2. for other activities B.W. Gibson et al. / The Journal of Biological Chemistry 266 (1991) 23103-23111. Bombinin-like peptides with antimicrobial activity from scin secreations from Asian toad, Bombina orientalis


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   18   MNFKYIVAVSILIASAYA    
Prepro25 RSEENDIQSLSQRDVLEEESLREIR   
BioactiveBombinin-like peptide 127NoGIGGALLSAAKVGLKGLAKGLAEHFAN   
Prepro46 GKRTAEEREVMKRLEAAMRDLDSFEHPEEASEKETRGFNQEEKEKR   
BioactiveBombinin-H20YesIIGPVLGLVGSALGGLLKKI 4.44.7