Ranalexin

Entry Ranalexin
Uniprot code P39084
Fasta P39084
Peptide names Ranalexin
Suborder Neobatrachia
Family Ranidae
Genus Lithobates
Species Lithobates catesbeianus
Ecozone Nearctic, Neotropic
Distribution Eastern North America, except southern Florida, north to Nova Scotia, New Brunswick, southern Quebec, and southern Ontario (Canada), west to the central plains and south to Hidalgo, Puebla, and adjacent Veracruz (Mexico); introduced on Cuba, Isla de Juventud (= Isla de Pinos), Puerto Rico, Hispaniola, and Jamaica in the Antilles; introduced widely in the rest of the world including the Netherlands, Bordeaux region of France, Belgium, northern Italy, western Spain, Crete, Malaya (Malaysia), Java, Bali, Japan, southern and western Mexico, northern Thailand, Korea, and Taiwan (China)
Antimicrobial & other activities antibacterial
Tissue Skin
Sequence MFTLKKSLLLLFFLGTINLSLCEEERNAEEERRDNPDERDVEVEKRFLGGLIKIVPAMIC
AVTKKC
Length 66
Signal peptide class Class-1
References:
1. for MIC/HC50 D.P. Clark et al. / The Journal of Biological Chemistry 269 (1994) 10849-10855. Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, stucturally related to the bacterial antibiotic, polymyxin


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MFTLKKSLLLLFFLGTINLSLC    
Prepro24 EEERNAEEERRDNPDERDVEVEKR   
BioactiveRanalexin20NoFLGGLIKIVPAMICAVTKKC 15.21.9