Dermaseptin-B3

Entry Dermaseptin-B3
Uniprot code P81485
Fasta P81485
Peptide names Dermaseptin-B3 Dermaseptin B3
Suborder Neobatrachia
Family Hylidae
Genus Phyllomedusa
Species Phyllomedusa bicolor
Ecozone Neotropic
Distribution Amazon Basin in Brazil, Colombia, Bolivia, and Peru; the Guianan region of Venezuela and the Guianas. Possibly to be found in eastern Ecuador
Antimicrobial & other activities antibacterial
Tissue Skin
Sequence MAFLKKSVFLVLFLGLVSLSICEEEKREEENEEKQEDDEQSEEKRALWKNMLKGIGKLAG
QAALGAVKTLVGAE
Length 74
Signal peptide class Class-1
References:
1. for MIC/HC50 P. Nicolas and C. El Amri / Biochimica et Biophysica Acta 1788 (2009) 1537-1550. The dermaseptin superfamily: a gene-based combinatorial library of antimicrobial peptides; S. Charpentier et al. / The Journal of Biological Chemistry 273 (1998) 14690-14697. Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MAFLKKSVFLVLFLGLVSLSIC    
Prepro23 EEEKREEENEEKQEDDEQSEEKR   
BioactiveDermaseptin-B329NoALWKNMLKGIGKLAGQAALGAVKTLVGAE>100.001.53.1
BioactiveDermaseptin B328NoALWKNMLKGIGKLAGQAALGAVKTLVGA 2.61.3