Dermaseptin-01

Entry Dermaseptin-01
Uniprot code P83637
Fasta P83637
Peptide names Dermaseptin-01 Dermaseptin DS 01 Dermaseptin-5 Dermaseptin-H6
Suborder Neobatrachia
Family Hylidae
Genus Phyllomedusa
Species Phyllomedusa oreades
Ecozone Neotropic
Distribution Plateaus in the states of Goias (Serra da Mesa, Chapada dos Veadeiros, Serra dos Pirineus), Minas Gerais (municipality of Cabaceira Grante), and in the Distrito Federal, above 900 m elevation, Brazil
Antimicrobial & other activities antibacterial, antifungal
Tissue Skin
Sequence
Length 29
References:
1. for MIC/HC50 G.D. Brand et al. / JBC 277 (2002) 49332-49340. Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells;  J.R.S.A. Leite et al. / Comparative Biochemistry and Physiology, Part A 151 (2008) 336-343. Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: Secondary structure, antimicrobial activity, and mammalian cell toxicity


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
BioactiveDermaseptin-0129YesGLWSTIKQKGKEAAIAAAKAAGQAALGAL 6.423.2