Dermaseptin-H6

Entry Dermaseptin-H6
Uniprot code P84936
Fasta P84936
Peptide names Dermaseptin-01 Dermaseptin DS 01 Dermaseptin-5 Dermaseptin-H6
Suborder Neobatrachia
Family Hylidae
Genus Phyllomedusa
Species Phyllomedusa azurea
Ecozone Neotropic
Distribution Chacoan regions of eastern Bolivia (Beni and Santa Cruz provinces), Paraguay, northern Argentina (Salta, eastern Jujuy, Formosa, Chaco, northern Santiago del Estero, Santa Fe, and Corrients provinces) and pantanal and cerrado regions of central and western Brazil (Rondonia, Mato Grosso, Mato Grosso do Sul, Tocantins, Goias, Distrito Federal, Minas Gerais, and Sao Paulo) with an isolated population in Santa Catarina, southern Brazil
Antimicrobial & other activities antibacterial, antifungal
Tissue Skin
Sequence
Length 29
References:
1. for MIC/HC50 G.D. Brand et al. / JBC 277 (2002) 49332-49340. Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells;  J.R.S.A. Leite et al. / Comparative Biochemistry and Physiology, Part A 151 (2008) 336-343. Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: Secondary structure, antimicrobial activity, and mammalian cell toxicity


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
BioactiveDermaseptin-H629YesGLWSTIKQKGKEAAIAAAKAAGQAALGAL 6.423.2