Esculentin-1S

Entry Esculentin-1S
Uniprot code Q1MU21
Fasta Q1MU21
Peptide names Esculentin-1S
Suborder Neobatrachia
Family Ranidae
Genus Odorrana
Species Odorrana schmackeri
Ecozone Palearctic, Indomalaya
Distribution Southern and south-central China in Henan, Shaanxi, Gansu, Sichuan, Guizhou, Hubei, Anhui, Jiangsu, Zhejiang, Hunan, Guangdong and Guangxi Provinces, at 200-1400 m elevation; reports from Vietnam and Thailand require confirmation
Antimicrobial & other activities antibacterial
Tissue Skin
Sequence MFTLKKPLLLIVLLGIISLTLCEQERAADEDEGSEIKRGLFSKFAGKGIKNMIIKGIKGI
GKEVGMDVIRTGIDVAGCKIKGEC
Length 84
Signal peptide class Class-1
References:
1. for MIC/HC50 T. Chen et al. / Genomics 87 (2006) 638-644. Cloning from tissue surrogates: Antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MFTLKKPLLLIVLLGIISLTLC    
Prepro16 EQERAADEDEGSEIKR   
BioactiveEsculentin-1S46NoGLFSKFAGKGIKNMIIKGIKGIGKEVGMDVIRTGIDVAGCKIKGEC 1.73