Dermaseptin sI

Entry Dermaseptin sI
Uniprot code Q7T3K6
Fasta Q7T3K6
Peptide names Dermaseptin-1 Dermaspetin DS S1 DS1 Dermaseptin sI
Suborder Neobatrachia
Family Hylidae
Genus Phyllomedusa
Species Phyllomedusa sauvagii
Ecozone Neotropic
Distribution The Chacoan region of eastern Bolivia, northern Paraguay, Mato Grosso do Sul (Brazil), and northern Argentina
Antimicrobial & other activities antibacterial, antifungal
Tissue Skin
Sequence MDILKKSLFLVLFLGLVSLSICEEEKRENEDEEKQEDDEQSEMKRALWKTMLKKLGTMAL
HAGKAALGAAADTISQGTQ
Length 79
Signal peptide class Class-1
References:
1. for MIC/HC50 A. Mor et al. / JBC 269 (1994) 31635-31641. The vertebrate peptide antibiotics dermaseptins have overlapping structural features but target specific microorganisms


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MDILKKSLFLVLFLGLVSLSIC    
Prepro23 EEEKRENEDEEKQEDDEQSEMKR   
BioactiveDermaseptin sI34NoALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ>70.0015