Brevinin-1Pb

Entry Brevinin-1Pb
Uniprot code Q8QFQ5
Fasta Q8QFQ5
Peptide names Brevinin-1Pb
Suborder Neobatrachia
Family Ranidae
Genus Lithobates
Species Lithobates pipiens
Ecozone Nearctic
Distribution Southern Canada (southeastern British Columbia to southern Northern Territory east to Labrador and Nova Scotia) south through eastern Washington eastern Oregon, Nevada and adjacent California to northern Arizona, northern New Mexico (with islolated populations along the Rio Grande south to Las Cruces), thence east-northeast to central Nebraska, Ohio, northern Kentucky, West Virginia, and New England, USA
Antimicrobial & other activities antibacterial, antifungal
Tissue Skin
Sequence MFTLNKFLLLLFFLGTINLSFCEEENAEEERIDEPDETDVEVEKRFLPIIAGIAAKVFPK
IFCAISKKC
Length 69
Signal peptide class Class-1
References:
1. for MIC/HC50 J. Goraya et al. / Eur. J. Biochem. 267 (2000) 894-900. Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MFTLNKFLLLLFFLGTINLSFC    
Prepro23 EEENAEEERIDEPDETDVEVEKR   
BioactiveBrevinin-1Pb24NoFLPIIAGIAAKVFPKIFCAISKKC 145