Kininogen-1c

Entry Kininogen-1c
Uniprot code Q90W88
Fasta Q90W88
Peptide names Maximakinin Kininogen-1c Bradykinin
Suborder Archeobatrachia
Family Bombinatoridae
Genus Bombina
Species Bombina maxima
Ecozone Palearctic, Indomalaya
Distribution Yunnan, southwestern Sichuan, Hubei, Guizhou, and northern Guangxi, China; adjacent northern Vietnam
Antimicrobial & other activities contraction of small intestine smooth muscle cells, relaxation of arterial smooth muscle cells
Tissue Skin
Sequence MRLWFCLSLFIVLCLEHFPGTLADERNVPESEEKTEQFLRDLPKINRKGPRPPGFSPFRG
KFHSQTLRDLPKINRKGPRPPGFSPFRGKFHSQTLRDLPKINRKGPRPPGFSPFRGKFHS
QSLRDLPKINRKGPRPPGFSPFRGKFHSQSHV
Length 152
Signal peptide class Class-5
References:
2. for other activities T. Chen et al. / Peptides 23 (2002) 1547-1555. Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis)


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   23   MRLWFCLSLFIVLCLEHFPGTLA    
Prepro17 DERNVPESEEKTEQFLR   
BioactiveMaximakinin19NoDLPKINRKGPRPPGFSPFR   
BioactiveBradykinin9NoRPPGFSPFR   
BioactiveMaximakinin19NoDLPKINRKGPRPPGFSPFR   
BioactiveBradykinin9NoRPPGFSPFR   
BioactiveMaximakinin19NoDLPKINRKGPRPPGFSPFR   
BioactiveBradykinin9NoRPPGFSPFR   
BioactiveMaximakinin19NoDLPKINRKGPRPPGFSPFR   
BioactiveBradykinin9NoRPPGFSPFR